产生二氧化碳依赖的扩展谱β-lactamase的埃舍里希亚大肠杆菌病与热炎相关:一个案例报告
Shinya Yamamoto1, Tatsuya Kobayashi1, Mahoko Ikeda1
1Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
概括
这项研究报告了一种罕见的二氧化碳依赖的,扩展光谱β-乳糖酶产生大肠杆菌引起炎症和细菌病的罕见病例. 这种独特的生长特征推迟了其在临床微生物学实验室的识别.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 细菌学 细菌学是一门学科.
背景情况:
- 大肠杆菌是尿路和血液感染的常见原因.
- 通常,大肠杆菌在临床实验室中很容易被识别出来.
- 产生扩展光谱β-乳糖酶 (ESBL) 的菌株带来了治疗挑战.
研究的目的:
- 报告一种独特的带有ESBL产生的大肠杆菌引起的细菌性炎症病例.
- 突出CO2依赖的增长所带来的诊断挑战.
- 强调考虑细菌鉴定不寻常生长条件的重要性.
主要方法:
- 一个62岁的男性患者的病例报告,他患有白炎和细菌血症.
- 对血液培养分离物的分析,由于CO2依赖的生长,鉴定延迟.
- 对于ESBL的确认,进行抗微生物敏感性测试和聚合酶链反应 (PCR).
主要成果:
- 该分离物被确定为产生ESBL的大肠杆菌,其异常的增长依赖于二氧化碳 (CO2).
- 在常规的有氧培养中,生长弱,但在5%的二氧化碳大气中,生长强.
- 聚合酶链反应证实了ESBL基因的存在.
结论:
- 这是第一次报告人体感染ESBL产生,依赖于二氧化碳的大肠杆菌的病例.
- 依赖于CO2的生长可以显著延迟致病细菌的识别.
- 快速准确的鉴定对于有效的抗微生物治疗和患者管理至关重要.
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