持续的葡萄糖监测导致怀孕的差异,有和没有不良周产期结果
Celeste Durnwald1, Roy W Beck, Zoey Li
1Maternal Fetal Medicine Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; the Jaeb Center for Health Research, Tampa, Florida; and the International Diabetes Center, HealthPartners Institute, St. Louis Park, Minnesota.
Obstetrics and gynecology
|October 17, 2024
概括
持续血糖监测 (CGM) 显示,在怀孕早期的高血糖水平与不良结果有关,如对妊娠年龄大的新生儿和妊娠高血压障碍 (HDP). 较低的葡萄糖水平与怀孕年龄较小的新生儿有关.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 不良的周产期结局,包括胎儿生长障碍和妊娠高血压障碍 (HDP),存在重大风险.
- 了解怀孕期间的血糖模式对于预测和潜在地预防这些并发症至关重要.
研究的目的:
- 调查妊娠早期持续血糖监测 (CGM) 衍生的血糖模式与周产期不良结果之间的关联.
- 具体来说,要确定血糖模式是否预测胎儿生长障碍 (大于妊娠年龄[LGA]和小于妊娠年龄[SGA]的新生儿) 和HDP.
主要方法:
- 一项前性观察性研究包括760名单独怀孕的参与者,并且没有先前存在的糖尿病.
- 参与者接受了至少14天的盲目持续血糖监测 (CGM).
- 从CGM中获得的血糖指标被分析并使用两样样本的t测试在具有和没有不良围产期结果的参与者之间进行比较.
主要成果:
- 出生LGA新生儿或被诊断患有HDP的参与者表现出更高的平均葡萄糖水平,并在整个妊娠期间花费更多时间的葡萄糖水平超过120 mg/dL和140 mg/dL.
- 这些关联不管妊娠糖尿病的状况如何,都持续存在.
- 与对照组相比,患有SGA新生儿的参与者平均葡萄糖水平较低,超过140 mg/dL的时间较短,低于63 mg/dL的时间较长.
结论:
- 妊娠早期平均葡萄糖水平升高和高血糖度持续时间增加与LGA新生儿和HDP相关.
- 相反,较低的平均葡萄糖水平和消耗低血糖时间的增加与SGA新生儿有关.
- 由CGM衍生的血糖模式为怀孕期间围产期风险预测提供了宝贵的见解.
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