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Updated: Jun 10, 2025

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

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开发新的Kir2.1通道开放剂,从芬类似物开发出来

Encan Li1, Najla Boujeddaine1, Marien J C Houtman1

  • 1Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

British journal of pharmacology
|October 17, 2024
PubMed
概括

研究人员将GPV0057确定为一种新的向内整流器通道 (IK1) 开启器. 这种化合物有效地增强IK1功能,为心力衰竭和相关通道病变提供了有前途的治疗候选者.

关键词:
在Kir2.1频道上播放.心脏药理学心脏药理学药物发现/目标验证在hiPSC-CMC中使用.离子通道 离子通道非目标效应的非目标效应甲的类似物

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