与土著人民进行定性基因组研究:对参与性实践的范围审查
Morgan Ehman1, Nadine R Caron2,3, Laurie Montour4
1Cancer Control Research, BC Cancer Research Institute, Vancouver, BC, Canada.
BMJ global health
|October 17, 2024
概括
原住民基因组学研究的定性方法促进社区参与和共同创造. 虽然报告了参与性实践,但随着研究的进展,其范围往往会下降,突出了土著基因组研究伙伴关系需要改进的领域.
科学领域:
- 基因组学就是基因组学.
- 定性研究是指质量研究.
- 土著研究土著研究.
背景情况:
- 原住民在基因组研究中仍然代表性不足.
- 定性方法可以促进与土著权利一致的包容性基因组资源.
- 由于历史背景,负责任和协作研究至关重要.
研究的目的:
- 确定涉及土著人民的发表的定性基因组研究中的参与性实践的范围和性质.
- 为开发包容性基因组资源和伦理研究指南提供信息.
- 为社区主导的基因组研究方法提供实际指导.
主要方法:
- 在多个数据库 (PubMed,CINAHL,Embase,Scopus,北美土著人文献) 进行系统的文献搜索.
- 包括使用定性方法对加拿大,美国,澳大利亚或新西兰土著人口的基因组学相关主题的研究.
- 将参与性实践抽象化和映射到一个伦理基因组研究框架中.
主要成果:
- 确定了17篇文章,展示了各种土著群体和环境中的各种方法.
- 报告的做法通常包括土著合作研究监管,社区参与和共同创建方法.
- 随着研究研究的进步,参与和社区主导的参与程度往往会下降.
结论:
- 非规范的土著基因组研究指南可以通过使用多种定性方法有效地应用.
- 结果强调了这些方法在实践中的适应性,并建议在整个研究生命周期中加强参与参与的机会.
- 描述的研究实践为旨在与土著社区建立强大的定性基因组研究伙伴关系的研究人员提供了宝贵的见解.
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