仅通过手术治疗的病理性T1N0食道状细胞癌的复发和预后预测因素
Manato Ohsawa1, Yoichi Hamai1, Manabu Emi1
1Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan.
Surgery
|October 17, 2024
概括
仅仅手术后的早期食道癌 (病理性T1N0) 的复发与差异化瘤和淋巴或血管的入侵有关. 这些因素预示着不良结果,表明需要更密切的随访和潜在的辅助治疗.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 病理学 病理学 病理学
背景情况:
- 仅用手术治疗的早期食道状细胞癌 (病理T1N0) 通常有良好的预后.
- 然而,在这些患者的一小部分人群中观察到复发,需要进一步调查.
- 确定复发预测因子对于优化患者管理至关重要.
研究的目的:
- 为了确定患有病理性T1N0食道状细胞癌的患者的复发和预后因素.
- 分析这个特定患者队列中的复发模式和生存率.
主要方法:
- 对124名患有病态T1N0食道状细胞癌的患者进行了回顾性分析,这些患者接受了R0切除的食道切除术.
- 使用单变量和多变量分析评估复发和预后因素.
- 卡普兰-梅尔生存率分析,以评估无复发和整体生存率.
主要成果:
- 五年无复发生存率为84.7%,五年整体生存率为87.2%.
- 在9.7%的患者中观察到复发.
- 差异化组织学类型和阳性淋巴和/或血管入侵是无复发生存的显著预测因素.
结论:
- 差异化瘤和淋巴/血管入侵是T1N0食道状细胞癌仅用手术治疗的复发和预后的关键预测因素.
- 患有这些不良因素的患者面临更高的复发率,通常是远程转移.
- 辅助治疗和更密切的监测可能有利于患有这些高风险特征的患者.
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
127
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
127
Barrett Esophagus-I: Introduction
78
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
78
Esophageal Strictures-I: Introduction
70
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
70


