酸沉积,三级甲状腺功能障碍,以及对移植的长期影响
John X Sun1, Kristin E Trone1, Ranish K Patel1
1Department of Surgery, Oregon Heath & Science University (OHSU), Portland, OR.
Surgery
|October 17, 2024
概括
三级甲状腺功能障碍症显著增加酸沉积的风险在移植. 然而,这种情况和沉积都没有影响研究中移植接受者的长期功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 内分泌学 在内分泌学.
背景情况:
- 三级性甲状腺功能增强症是一种已知的并发症,影响移植结果.
- 酸沉积被假定有助于这些患者的全移植功能障碍.
研究的目的:
- 为了研究移植中的酸沉积的危险因素.
- 为了确定酸沉积和三级甲状腺功能增强症对全移植功能的影响.
主要方法:
- 从2017-2019年对159名脏移植接受者的回顾性审查.
- 移植后3个月和12个月的全移植活检分析酸沉积.
- 统计分析包括千二测试,t测试和多变量回归.
主要成果:
- 在37.1%的患者中诊断出三级性副甲状腺功能障碍症.
- 较长的手术前透析复古和cinacalcet使用与三级副甲状腺功能障碍症有关.
- 酸沉积发生在61%的三级甲状腺功能障碍症患者中,而23%的患者没有 (P < .001).
- 三级甲状腺功能障碍是酸沉积的重要危险因素 (OR,6.01;P < .001).
结论:
- 较长的手术前透析和cinacalcet的使用是三级副甲状腺功能障碍的危险因素.
- 三级甲状腺功能障碍是移植后酸沉积的主要危险因素.
- 无论是酸沉积还是三级副甲状腺功能障碍症都与3年后显著降低膜过率无关.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
2
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
2
Chronic Kidney Disease III: Interprofessional Care
2
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
2
Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3
Acute Kidney Injury II: Pathophysiology
2
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2
Acute Kidney Injury III: Clinical Manifestations
2
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
2
Chronic Kidney Disease I: Introduction
2
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
2


