用替代性有的对比剂代替以防止与其使用相关的反复不良药物反应:一个元分析
Su Jin Lim1, Pae Sun Suh2, Chong Hyun Suh3
1Department of Radiology, National Cancer Center, Seoul, Republic of Korea.
European radiology
|October 17, 2024
概括
切换到不同的有的对比介质 (ICM) 显著减少了69%的复发药物不良反应 (ADRs). 使用没有常见的卡巴莫伊尔侧链的ICM可以额外减少35%的副作用.
科学领域:
- 放射学和成像学 放射学和成像学
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
背景情况:
- 离子对比介质 (ICM) 广泛用于医学成像.
- 对ICM的不良药物反应 (ADR) 可能会发生,复发是对患者安全的担忧.
- 缺乏规范的指导方针,以预防复发的ICM相关的ADR.
研究的目的:
- 系统地审查和元分析ICM相关的副作用的复发率.
- 评估使用替代ICM的预防效果,特别是那些缺乏常见的卡巴莫伊尔侧链的ICM.
主要方法:
- 在MEDLINE和EMBASE数据库中进行了系统的文献搜索.
- 包括的研究重点是那些在索引ICM反应后接受了对比增强计算机断层扫描的患者.
- 使用随机效应模型计算了聚合的复发率和赔率比率,并对ICM替代进行了子组分析.
主要成果:
- 分析了十篇原创文章 (2001年6月至2021年3月).
- 与ICM相关的副作用的综合复发率为16.6%,类似于过敏反应 (15.5%).
- 替代ICM可减少69% (或0.31) 的复发性不良反应,在使用缺乏常见carbamoyl侧链 (或0.65) 的ICM时,额外减少35%.
结论:
- 替代性ICM替代可以显著减少反复复发的ADR.
- 缺乏常见的卡巴莫伊尔侧链的ICM可以更好地预防复发的副作用.
- 这项研究支持在临床上使用没有常见卡尔巴莫伊尔侧链的替代ICM,以预防复发的副作用.
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