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孕产妇和新生儿因素对沃顿果介质干细胞产量的影响

Ranim Mahmoud¹, Mohamed Bassiouny¹, Ahmed Badawy²

¹Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Scientific reports

|October 17, 2024

概括

沃顿的果衍生的介质干细胞 (WJ-MSCs) 对再生医学具有前景. 较年轻的母亲年龄,更高的妊娠年龄和增加的出生体重对WJ-MSC产量产生了积极的影响,指导了供体选择.

科学领域:

干细胞生物学干细胞生物学
再生医学是一种再生医学.
产科产科产科产科产科

背景情况:

沃顿的果衍生的介质干细胞 (WJ-MSCs) 是再生医学的宝贵资源,由于可访问性和道德考虑.
优化WJ-MSC产量对于临床应用至关重要,需要了解影响因素.
关于WJ-MSC采集的决定需要全面了解影响细胞数量的参数.

研究的目的:

调查母亲和新生儿变量对WJ-MSC产量的影响.
确定影响WJ-MSC扩散和翻倍时间的关键因素.
为了确定特定的供体特征和WJ-MSC数量之间的相关性.

主要方法:

从79个带样本中分离和扩展WJ-MSCs.
评估人口翻倍的时间和细胞增殖.
流细胞测量分析以确认WJ-MSC的身份 (CD105+,CD90+,CD73+,CD45-,CD34-).

主要成果:

在带宽度和人口翻倍时间之间观察到负相关性.
母亲年龄与WJ-MSC产量有显著的负相关性.
增加的妊娠年龄和出生体重与WJ-MSC产量正相关.

结论:

WJ-MSC产量受到母亲和新生儿因素的影响,较年轻的母亲年龄,更高的妊娠年龄和更大的出生体重是有利的.
这些发现为在再生医学中选择最佳捐赠者提供了关键的见解.
带宽度可能会影响WJ-MSC的增殖率.

关键词:

流动细胞计量流动细胞计量母亲的母亲的母亲新生儿新生儿新生儿新生儿干细胞是一种干细胞.沃顿的果沃顿的果收益率收益率是指收益率.

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