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作为对个性化新生儿补充方案的反应,体内生长结果

Elliot J Stalter¹, Silvia L Verhofste¹, John M Dagle¹

¹Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa, IA, USA.

Journal of perinatology : official journal of the California Perinatal Association

|October 17, 2024

概括

协议化 (Na) 补充剂改善了极度早产婴儿的生长和减少了机械通风时间. 这种方法并没有增加这种脆弱人群中常见疾病的发病率.

科学领域:

新生儿医学新生儿医学
儿童营养学儿童营养学
临床护理儿科临床护理儿科

背景情况:

优化 (Na) 平衡对于早产婴儿至关重要.
目前的补充方案缺乏标准化,特别是在尿液Na监测方面.
有效的Na管理对极度早产新生儿的生长和临床结果产生影响.

研究的目的:

以尿液Na度为指导的新型Na补充方案的影响进行评估.
评估对生长参数的影响以及早产婴儿患病率.

主要方法:

追溯队列研究比较婴儿在 (2012-15年) 之前和 (2016-20年) 之后实施议定书.
包括26~33~6~7周的婴儿妊娠年龄 (GA).
分析了使用通用线性模型的生长 (体重,头周长) 和发病率.

主要成果:

对于26~29周的婴儿,该方案改善了体重和头周长z-score.
与相同子组的机械通风持续时间的减少有关.
对30-33^6/7周的婴儿的生长没有显著影响GA;高血压,高血,BPD,NEC或败血症的增加没有.

结论:

协议化Na补充剂对生长产生积极影响,并减少极度早产婴儿的机械通风需求.
这种基于证据的方法似乎是安全的,不会增加主要新生儿疾病的风险.

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