较大的幽默性EBV反应可能与慢性多发性多发性硬化症进展的胆脉炎有关
Dejan Jakimovski1,2, Robert Zivadinov3,4, Murali Ramanathan5
1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY, 14203, USA. djakimovski@bnac.net.
Journal of neurovirology
|October 17, 2024
概括
爱斯坦-巴尔病毒 (EBV) 感染可能会在患有多发性硬化症 (pwMS) 的人中恶化胆 (choroid plexus) 神经炎症,特别是在进展阶段. 这表明EBV和晚期MS病理之间存在联系.
科学领域:
- 神经免疫学 神经免疫学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 在多发性硬化症 (MS) 中,可用MRI测量胆管 (CP) 炎症.
- 爱斯坦-巴尔病毒 (EBV) 和多发性硬化症的CP变化之间的关联尚未得到充分理解.
研究的目的:
- 为了研究EBV幽默反应与MS (pwMS) 患者的CP炎症之间的关系.
- 为了比较复发性复发性MS (RRMS) 和进展性MS (PMS) 患者之间的CP特征.
主要方法:
- 170名pwMS接受了MRI测量CP体积和伪T2 (pT2) 放松时间.
- 量化了幽默性抗EBV抗体 (抗EBNA-1 IgG和抗VCA IgG) 的数量.
- 根据年龄和治疗效果调整后的统计分析.
主要成果:
- 进展性多发性硬化症 (PMS) 患者的CP pT2值明显高于复发性复发性多发性硬化症 (RRMS) 患者 (1120ms vs. 954ms,p=0.037).
- 在对共变量进行调整后,在PMS患者中,较高的CP pT2值与高的抗EBNA-1 IgG水平相关 (r=0.352,p=0.015).
结论:
- 在pwMS中抗EBV幽默反应的升高可能与CP神经炎症的增加有关.
- 这种关联在MS的渐进,晚期阶段显得更加明显.
- 需要进一步的大规模研究来证实在渐进性多发性硬化症亚型中的概括性.
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