基底前脑连接在新皮层的多模式梯度
Sudesna Chakraborty1,2,3, Roy A M Haast4,5,6, Kate M Onuska7,4,8
1Neuroscience Graduate Program, Western University, London, Ontario, Canada. schakr28@uwo.ca.
Nature communications
|October 17, 2024
概括
基底前脑 (BF) 胆能预测显示了人类大脑中的组织梯度. 这种梯度与大脑区域如何连接以及神经元分支的复杂性有关,影响皮质整合.
科学领域:
- 神经科学是一个神经科学.
- 神经解剖学是一个神经解剖学.
背景情况:
- 皮层胆固醇突起起源于基础前脑 (BF).
- 了解BF预测的组织对于破译认知功能至关重要.
- 之前的研究已经暗示了BF次区域的专业化,但缺乏详细的映射.
研究的目的:
- 调查人类基底前脑 (BF) 胆预测的组织原理.
- 绘制BF及其皮层目标内部结构和功能连接的梯度.
- 为了将BF连接性与分子标记物和轴突树木化模式相关联.
主要方法:
- 结合7T扩散MRI和静止状态功能MRI来计算多模式BF连接梯度.
- 使用[18F]甲-二萨米 (FEOBV) PET成像来测量囊泡性乙胆载体 (VAChT) 度.
- 在小鼠中使用病毒追踪来研究BF胆固醇投射和轴突树木化.
主要成果:
- 观察到结构功能连接性降低的梯度,从前中向后侧BF连接,在Meynert的基底核中最低.
- 这种BF梯度与新皮层中类似的梯度相对应,从单模向跨模区域,特别是中环岛网络.
- 用FEOBV PET测量的皮层VAChT度,与此连接度梯度空间相关.
- 鼠标模型证实了BF胆固醇轴突树木化的梯度.
结论:
- 基底前脑表现出其胆性投射的地形组织.
- 胆固醇神经元子群体在轴突复杂性上有所不同,这影响了它们与皮质点的功能整合.
- 这些发现为人类大脑中胆固醇神经调节的神经解剖学基础提供了洞察力.
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