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Updated: Jun 10, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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在炎症性肠道疾病中,N4BP3通过调解K63-链接的RIPK2无处可见化来促进NOD2-MAPK/NF-κB通路

Wang Jiang1, Yan Zhao2, Min Han3

  • 1Department of Digestive Diseases, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, 161 Shaoshan Road, Changsha, 410000, China.

Cell death discovery
|October 17, 2024
PubMed
概括

在炎症性肠病 (IBD) 中,NOD2信号传递至关重要. 这项研究确定了N4BP3作为一个关键调节器,与RIPK2相互作用,通过IBD中的NOD2-MAPK/NF-κB通路促进炎症.

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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