在COVID-19之前和期间中央早熟青春期频率的比较:系统性审查和元分析
Jianwei Zhang1, Jinliang Xu1, Xiaoli Tang1
1Shaoxing Maternity and Child Health Care Hospital, Shaoxing, 312000, China.
BMC endocrine disorders
|October 17, 2024
概括
中央早期青春期 (CPP) 在COVID-19大流行期间显著增加. 需要进一步的研究来了解导致早期青春期增加的因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 中部早发性青春期 (CPP) 是一种青春期异常早开始的情况.
- COVID-19 流行病与儿童的各种健康变化有关,需要对其对内分泌疾病的影响进行调查.
研究的目的:
- 在COVID-19大流行期间评估中心早期青春期 (CPP) 的患病率.
- 通过系统性审查和元分析,比较大流行前和期间的CPP发病率.
主要方法:
- 按照PRISMA指南进行了系统审查和元分析.
- 在PubMed,Embase,Web of Science和WANFANG数据库中进行了搜索 (2019年1月 - 2023年3月).
- 包括对15岁以下儿童的研究,定义了CPP标准,比较了大流行前和大流行期间.
主要成果:
- 分析包括17项研究.
- 在COVID-19大流行期间,CPP发生率显著增加 (OR = 2.57;95% CI,1.85-3.56).
- 在大流行期间,在CPP患者中观察到BMI SDS的轻微而非显著增加.
结论:
- 在COVID-19大流行期间,CPP频率显著增加.
- 这些发现突出了大流行病与早期青春期发作之间的潜在联系.
- 建议进行进一步的大规模队列研究,以确定特定的致病因素.
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