核WWOX/TRAF2开关的解离在低温下导致UV/冷冲击介导的核泡细胞死亡

Szu-Jung Chen1, Cheng-Chang Tsai1, Sing-Ru Lin1

  • 1Institute of Molecular Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.

概括

具有功能性瘤抑制剂WW域含氧化还原酶 (WWOXf) 的正常细胞在暴露于紫外线和寒冷时经历泡细胞死亡 (BCD). 缺乏WWOX的细胞经历了不同的死亡途径. 温度通过WWOX/TRAF2复合体决定细胞死亡的命运.

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