坚持低脂肪饮食模式可以降低头癌的风险:来自PLCO试验的证据
Rong Wang1, Haoyun Luo2, Yijing Ye3
1Department of Radiation Oncology, Zhongshan City People's Hospital, No.2, Sun Wen East Road, Zhongshan, 528400, Guangdong, China. wangrongfypl@126.com.
Nutrition journal
|October 17, 2024
概括
坚持低脂肪饮食 (LFD) 模式可能会降低患头癌 (HNC) 的风险. 这项研究发现,在美国人口中,较高的LFD得分和较低的HNC发生率之间存在显著的关联.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 头部和部癌症 (HNC) 代表了全球健康的重大负担.
- 饮食模式越来越被认为是各种癌症的可修改风险因素.
- 了解特定饮食模式,如低脂肪饮食在HNC预防中的作用至关重要.
研究的目的:
- 调查遵守低脂肪饮食 (LFD) 模式与头癌 (HNC) 风险之间的关联.
- 检查LFD坚持和HNC风险之间的剂量反应关系.
- 为了探索与HNC亚型的关联.
主要方法:
- 利用前列腺,肺,结肠直肠和卵巢 (PLCO) 癌症查试验的数据.
- 使用经过验证的低脂肪饮食 (LFD) 评分评估饮食坚持.
- 采用考克斯回归和限制立方支线图片来分析LFD得分和HNC风险之间的关联.
- 进行子组和灵敏度分析以确保稳定性.
主要成果:
- 总共分析了98,459名参与者,在8.8年内发现了268例HNC病例.
- 对LFD模式的更高坚持与HNC风险降低有显著的关联 (HR 0.60;P趋势=0.026).
- 对于喉癌 (HR 0.46;P趋势=0.039) 也观察到一个显著的反向关联,具有线性剂量反应关系.
结论:
- 研究结果表明,采用低脂肪饮食模式可能是预防头癌的保护因素.
- 坚持LFD模式与美国人口中HNC风险较低有关.
- 进一步的研究可以在LFD模式中探索特定的食物成分.
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