狼性炎患者死亡率的性别差异
Wang Xiang1,2, Xi Xia1,2, Yuewen Lu1,2
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, 58th, Zhongshan Road II, Guangzhou, 510080, China.
European journal of medical research
|October 18, 2024
概括
男性狼性炎 (LN) 患者面临更高的死亡率,特别是感染,尽管类似的病理. 了解这些性别差异对于改善LN患者护理和治疗结果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 狼性炎 (LN) 是系统性红斑狼的一个严重表现.
- 在自身免疫性疾病中,越来越多地认识到疾病呈现和结果的基于性别的差异.
研究的目的:
- 在活检确认的狼性炎患者的大队伍中调查性别的预后意义.
- 鉴定LN死亡率和不良结局的性别特异性风险因素.
主要方法:
- 在1996年至2018年期间诊断的1048名活检证明的LN患者的回顾性分析.
- 评估人口统计,临床数据,实验室发现和病原学.
- 考克斯回归模型用于评估与性别相关的死亡率和脏事件风险 (血清肌素的翻倍,末期脏疾病).
主要成果:
- 男性患者 (17%) 呈现出更具侵略性的疾病特征,包括高血压,早期发病,以及较差的功能标志物.
- 尽管整体病理情况相似,但男性表现出更严重的病学变化.
- 死亡率在男性 (24.2%) 与女性 (13.4%) 相比显著高,感染是导致死亡的主要原因,在男性中也更为普遍.
- 对于二次性结结果,没有观察到任何显著的性别差异.
结论:
- 男性性别是狼性炎死亡率的独立风险因素.
- 感染是LN患者的主要死亡原因,男性的死亡率不成比例.
- 解决性别差异对于优化狼性炎患者的管理和护理至关重要.
更多相关视频
相关概念视频
Comparing the Survival Analysis of Two or More Groups
156
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
156
Nephrotic Syndrome I : Introduction
2
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
2
Nephrotic Syndrome III : Nursing Management
2
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
2
Factors Affecting Renal Clearance: Renal Impairment
59
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
59
Nephrotic Syndrome II : Assessment and Medical Management
2
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
2
Renal Failure: Dose Adjustments
68
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
68


