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相关概念视频

Mismatch Repair01:20

Mismatch Repair

4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K
Protein Complex Assembly02:41

Protein Complex Assembly

10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

949
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
949
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

465
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
465

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相关实验视频

Updated: Jun 10, 2025

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &#946;2-Microglobulin
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

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MHConstructor:一个高通量,基于哈普类型的解决方案来解决MHC组装挑战.

Kristen J Wade1, Rayo Suseno1, Kerry Kizer1

  • 1Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.

Genome biology
|October 18, 2024
PubMed
概括

人类主要组织相容性复合体 (MHC) 的高遗传多样性挑战了DNA测序. MHConstructor提供了一个新的 de novo 组装工具,用于在大群体中准确的MHC分析.

关键词:
在新的组装 De novo.哈普洛型是指一种类型.人类白细胞抗原基因主要的组织相容性复杂.短读序列的测序方式

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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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相关实验视频

Last Updated: Jun 10, 2025

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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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科学领域:

  • 基因组学就是基因组学.
  • 人类遗传学 人类遗传学
  • 生物信息学是一种生物信息学.

背景情况:

  • 人类主要组织相容性复合体 (MHC) 表现出极端的遗传多态性.
  • 基于参考的对齐方法对于MHC序列组合是有限的,因为它的高可变性.

研究的目的:

  • 开发一种新的生物信息管道,用于人类MHC的新组装.
  • 为了从短读数据中实现高通量,可重现的MHC序列分析.

主要方法:

  • 将一个短读,de novo组装算法集成到一个专门的工作流中.
  • 开发MHConstructor,一个用于MHC组装的集装箱管道.
  • 适用于全基因组测序和目标捕获短读数据.

主要成果:

  • MHConstructor提供了一个独立的工具,用于从短读数据 de novo MHC 组装.
  • 该管道支持在人口队伍中进行高通量和可重复的分析.
  • 可实现无对齐的MHC序列分析.

结论:

  • MHConstructor克服了MHC组装基于参考方法的局限性.
  • 便于更广泛地获取高质量的MHC序列数据.
  • 对于人口遗传学和个性化医学研究至关重要.