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在严重抑郁症中,thalamocortical电路的异常动态功能连接性是主要的抑郁症

Weihao Zheng¹, Qin Zhang¹, Ziyang Zhao¹

¹Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China.

Journal of Zhejiang University. Science. B

|October 18, 2024

概括

重度抑郁症 (MDD) 与在甲状腺皮层系统中改变的动态功能连接 (dFC) 有关. 患有MDD的患者表现出异常的dFC模式,并减少了负面连接状态的时间,影响了情绪和认知.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
功能神经成像功能神经成像

背景情况:

脑皮层电路对于情绪和认知至关重要.
大型抑郁症 (MDD) 与改变的甲状腺皮层功能连接 (FC) 有关.
在MDD中,甲状腺皮层连接的动态方面尚不清楚.

研究的目的:

调查患有MDD的个体体体内 thalamocortical动态功能连接 (dFC) 的时间变化的变化.
为了检查动态横向性及其在MDD的thalamocortical系统的变化.
为了将动态的甲状腺皮层测量与MDD的临床症状相关联.

主要方法:

分析了48名MDD患者和57名健康对照者的休息状态功能磁共振成像 (fMRI) 数据.
在十个thalamic子区域和七个皮质子网络之间计算动态FC (dFC).
动态横向性分析和与临床评估的相关性.

主要成果:

与HC患者相比,MDD患者表现出较短的时间和过渡,处于负连接状态.
患有MDD的患者表现出甲状腺皮层功能横向性的波动增加.
在MDD中观察到涉及高阶皮质网络的异常dFC变异性,与症状严重程度相关.

结论:

MDD的特点是皮层dFC的异质变化,影响主要和更高阶皮质网络.
这些动态连接异常可能是MDD感官和认知处理缺陷的基础.
这些发现强调了动态连接在理解MDD神经生物学方面的重要性.

关键词:

动态功能连接的动态功能连接动态横向性的动态横向性大型抑郁症主要是抑郁症.静止状态功能磁共振成像技术甲状腺皮层的电路系统.

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