在喉回流的进展:病因,诊断和管理
Tina L Samuels1, Jennifer Aoun2, Inna Husain3
1Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Annals of the New York Academy of Sciences
|October 18, 2024
概括
喉回流 (LPR) 是一个子类型的频谱,而不是单一的疾病. 了解这些亚型有助于制定针对LPR症状的个性化治疗计划.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 消化系统疾病 消化系统疾病
背景情况:
- 喉回流 (LPR) 在上空消化道中呈现出多样化,非特异性的症状.
- LPR被理解为一个子类型的频谱,每个都有独特的临床表现和潜在机制.
- 症状是由于反流的直接/间接影响,粘膜损伤和神经对食道事件的反应造成的.
研究的目的:
- 探索喉回流 (LPR) 的复杂病因.
- 突出LPR诊断和管理中的挑战.
- 讨论亚型识别在指导治疗决策中的作用.
主要方法:
- 审查目前对LPR病理生理学的理解.
- 讨论诊断工具,包括下-食道多通道内阻抗-pH监测.
- 评估治疗策略,如阿尔金酸盐,抗逆流体手术和素抑制剂.
主要成果:
- 反流体成分会引起不同的粘膜反应和不同的症状持续时间.
- 低-食道多通道内阻抗-pH监测为个性化治疗提供了详细的反流分析,但面临着可访问性的限制.
- 喉过敏症需要在全面的LPR管理中考虑.
结论:
- 识别LPR亚型对于有效的个性化治疗策略至关重要.
- 虽然诊断和管理方面的挑战仍然存在,但正在进行的研究提供了新的见解和治疗方法.
- 一种多模式的方法,包括解决喉过敏症,对于管理LPR至关重要.
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