肠道微生物群与自闭症谱系障碍之间的关系:发展和治疗
Lisa Poupard1, Guylène Page1,2, Vincent Thoreau1,2
1Medicine and Pharmacy Faculty, University of Poitiers, Poitiers, France.
概括
患有自闭症谱系障碍 (ASD) 的儿童的肠道疾病 (GD) 与特定的细菌特征和胃肠道问题有关. 像益生菌这样的治疗方法看起来很有前途,但需要进一步的研究来开发标准化的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群显著影响大脑发育.
- 肠道微生物群 (GM) 容易受到导致肠道疾病 (GD) 的因素的影响.
- 新兴研究将GD与神经和行为障碍联系起来,包括自闭症谱系障碍 (ASD).
研究的目的:
- 审查影响转基因基因的产前和产后因素.
- 详细说明ASD儿童的特定肠道细菌特征.
- 探索ASD发展中的肠-大脑轴机制.
主要方法:
- 审查关于肠道微生物群和ASD的现有文献.
- 对详细分析ASD肠道细菌特征的研究进行分析.
- 检查将转基因与ASD联系在一起的拟议机制.
主要成果:
- 在患有ASD的儿童中,特定的肠道细菌特征被确定.
- 双向肠-大脑通信涉及神经炎症和改变的神经保护因子 (例如,短链脂肪酸).
- 神经递质失衡 (血清素,GABA) 可能导致ASD的肠-大脑相互作用.
结论:
- 在ASD中,GD可能是通过益生菌,益生菌或便微生物群移植部分可逆的.
- 目前的治疗方法面临局限性:治疗时间短,样本大小小,方案多样化.
- 针对GD的标准化,大队列治疗方法可以改善ASD的胃肠道和行为症状.
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