MAPbrain:一个灵长类动物大脑的多学科地图
Liangchen Zhuo1,2, Mengdi Wang1,2, Tingrui Song1
1Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Nucleic acids research
|October 18, 2024
概括
MAPbrain是一本关于灵长类动物大脑发育的新型多学科地图. 它整合了多样化的数据集,以探索跨物种和生命阶段的基因表达和细胞类型,帮助神经系统疾病研究.
科学领域:
- 神经科学是一个神经科学.
- 基因组学就是基因组学.
- 发展生物学 发展生物学
背景情况:
- 大脑发育是一个终身的,基因引导的过程,对认知功能和理解神经系统疾病至关重要.
- 多omics技术提供了全面的见解,但给数据集成和分析带来了挑战.
研究的目的:
- 介绍MAPbrain,一个灵长类动物大脑的多omics地图,旨在促进大脑发育的探索.
- 为整合和分析来自灵长类大脑的多种多omics数据提供一个强大的平台.
主要方法:
- 整合和规范化已发布和公开的多omics数据 (转录组学,表观组学,空间转录组学).
- 包括来自38个大脑区域和436个子区域的2100万个脑细胞的数据.
- 在胚胎和成年阶段收集数据,包括人类和非人类灵长类动物的164个时间点.
主要成果:
- MAPbrain提供了一个交互式平台,用于探索细胞类型和时间点特定的标记物.
- 该地图使得在大脑区域,物种和发育阶段之间进行基因表达比较.
- 促进转录组和表观组数据的联合分析,以及跨物种细胞类型导航.
结论:
- MAPbrain为全面的大脑发育研究提供了宝贵的资源.
- 该平台支持对灵长类大脑中的基因调节和细胞多样性的深入分析.
- 一个集成的在线模块允许用户在MAPbrain框架内分析自己的数据.
相关概念视频
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:26Cerebrum: Anatomical Overview I
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
01:19Brainstem
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
01:30Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).