在慢性外围神经病痛中出现过度病变的迹象
Malin Erika Carmland1,2, Melissa Dall Kreutzfeldt3, Peter Kolind Brask-Thomsen1,2
1Department of Clinical Medicine, Danish Pain Research Center, Aarhus University, Aarhus, Denmark.
European journal of pain (London, England)
|October 18, 2024
概括
这项研究质疑神经性疼痛患者的过度病变概念,发现过度病变的迹象并不一致地聚集在一起. 需要进一步的研究来定义这种唤起疼痛综合征.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
- 感官科学 感官科学
背景情况:
- 神经病痛是由体感官系统损伤引起的,呈现为自发或引起的疼痛.
- 催生疼痛的一种类型 - - 超情感 (Hyperpathia) 的定义很差,文献和定义不一致.
- 对于疼痛症状学来说,理解高发病症至关重要,需要明确的定义和对病理生理学的知识.
研究的目的:
- 在患有外围神经病痛的患者中研究机械性过度病变.
- 通过定量感官测试与其他感官发现相关联.
- 检查刺激-反应曲线和重复性针刺测试结果与过度病情相关.
主要方法:
- 研究了124名患有外围神经病痛的患者.
- 利用分级的针刺刺激用于刺激-反应曲线和重复刺激用于疼痛评估.
- 根据的刺激-反应或重复的针刺曲线对患者进行分组,以评估过度病变的可能性.
主要成果:
- 显示急剧刺激-反应曲线的患者与显示急剧重复针刺曲线的患者没有重叠.
- 这两组高病情暗示组更频繁地呈现出降低,而不是增加,检测和疼痛值.
- 这些发现挑战了作为一个独特的综合征的高发病症的凝聚性.
结论:
- 这项研究表明,过度病情的概念可能需要重新评估.
- 进一步的研究是必要的,以确定哪些症状和迹象同时出现,形成一个可定义的综合征.
- 澄清高通病的临床表现和病理生理学仍然是一个重要的研究目标.
相关概念视频
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
3
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
3
01:20Pain
468
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
468
01:44Nociception
27.7K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.7K
01:26Peripheral Artery Disease IV: Nursing Management
3
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
3
01:30Peripheral Artery Disease I: Introduction
3
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
3
01:25Analgesia and Pain Management
540
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
540