儿科患者下垂体茎加厚:一个未被认可的诊断?
Diego Zepeda1, Francisco Javier Guarda2,3, Cecilia Okuma4,5
1Universidad de Chile Facultad de Medicina Instituto de Investigaciones Materno Infantil Santiago Chile Instituto de Investigaciones Materno Infantil (IDIMI), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Archives of endocrinology and metabolism
|October 18, 2024
概括
儿童下垂体茎增厚 (PST) 很少见,特别是在拉丁美洲. 这项研究发现,生殖细胞瘤是智利儿科患者PST的主要原因,突显了迅速诊断和治疗的必要性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经瘤学神经瘤学
- 罕见疾病 罕见疾病
背景情况:
- 垂体茎加厚 (PST) 是一种罕见的儿科疾病,在拉丁美洲人口中数据有限.
- 在这个地区描述PST对于了解其患病率和病因学至关重要.
研究的目的:
- 为了全面描述2020年至2022年间在智利被诊断患有PST的儿科患者.
- 在这个群体中确定PST的主要原因和临床表现.
主要方法:
- 对被诊断患有PST的儿科患者 (<18岁) 的医疗记录的回顾性审查 (垂体插入时的茎宽度≥3毫米和/或光学隙时的茎宽度≥4毫米).
- 文献审查,将发现与现有的全球数据进行比较.
- 活检确认用于诊断.
主要成果:
- 确定了9名患有PST的儿科患者 (平均年龄为10.36岁).
- 常见的症状包括多滴水症,多尿症 (100%),生长不良 (77.8%).
- 生殖细胞瘤是主要病因 (8/9名患者),观察到的频率是智利预期的两倍. 所有患者都出现了阿尔金因血管压素 (AVP) 缺乏和至少一个前垂体激素缺乏.
结论:
- 在研究的智利儿科队列中,生殖细胞瘤是PST的主要原因.
- 准确的诊断和及时的治疗启动对于管理儿科PST至关重要.
- 加强区域数据收集对于改善儿童PST的理解和结果至关重要.
相关概念视频
Adrenal Gland Disorders
1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K
Attention-Deficit/Hyperactivity Disorder
47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47
Mitral Stenosis I: Introduction
2
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K


