在之前接受过减肥手术的患者中,由于levothyroxine吸收不良而导致的myxedema昏迷
Caterina Buoso1, Maria Cavadini1, Paolo Facondo1
1University of Brescia Department of Clinical and Experimental Sciences Brescia Italy Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, Azienda Socio-Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy.
Archives of endocrinology and metabolism
|October 18, 2024
概括
患有吸收不良的患者,通常是在减肥手术后,由于吸收受损,可能需要更高的勒沃西 (L-T4) 剂量. 这一案例凸显了严重甲状腺功能低下的风险,并表明液体L-T4可能会改善吸收.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 手术科学 手术科学
背景情况:
- 利沃铁素 (L-T4) 的吸收主要发生在阴和阴中,并受到胃酸度的影响.
- 腹腔外科手术,特别是胆腺转移,可以显著损害口服L-T4的吸收,导致增加剂量要求.
- 吸收不良综合征在治疗甲状腺功能低下症方面存在挑战,可能导致严重的临床表现.
研究的目的:
- 呈现一个有胆囊转移和吸收不良史病史的患者中化昏迷的病例.
- 讨论L-T4吸收受损的患者治疗甲状腺功能低下的挑战.
- 突出在吸收不良状态下替代L-T4配方的潜在好处.
主要方法:
- 一个年轻男性患者的病例报告呈现出肌性昏迷的症状.
- 审查患者的病史,包括之前的腹手术 (双腺转移).
- 静脉注射 (IV) L-T4,口服液体L-T4,口服氨酸 (L-T3),内类药物和支持性护理的使用.
主要成果:
- 该患者出现了严重的甲状腺功能低下症,低血糖,精神状态改变,低血压,心肌梗塞和低温症.
- 最初的基于平板电脑的L-T4疗法由于吸收不良而不足.
- 过渡到IVL-T4,液体口服L-T4和L-T3导致了逐渐的临床改善.
结论:
- 患有吸收不良的患者中L-T4吸收受损,特别是腹部外科手术后,可能导致严重的甲状腺功能低下症.
- 经常监测甲状腺刺激激素 (TSH) 对于经历了减肥手术的患者至关重要.
- 在吸收不良的患者中,L-T4的液体配方可能比平板药物提供更好的吸收和治疗效果.
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