高度过早的心房复杂负担和功能下降的风险
Chao-Yu Chen1,2, Chih-Hen Yu3,4, Po-Tseng Lee1,3
1Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Clinical kidney journal
|October 18, 2024
概括
每天高的过早心房综合体 (PACs) 负担与严重的脏不良事件增加有关,类似于心房动 (AF). 这一发现凸显了PACs作为病进展的重要风险因素.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 心房动 (AF) 与功能下降和末期病有关.
- 过早的心房综合体 (PACs) 可能表明心房肌病,并预测不良结果.
- 高PAC负担与脏结果之间的关联尚未得到充分理解.
研究的目的:
- 调查每日过度的PAC负担与重大脏不良事件之间的关系.
- 为了比较与高PAC负担相关的风险与心房动.
主要方法:
- 从霍尔特监测记录 (2011-2018) 中对10,981名患者进行了回顾性队列研究.
- 患者分为高PAC负担 (≥100/天),低PAC负担 (<100/天) 和AF组.
- 倾向性得分匹配用于平衡混因素;主要结局是主要的脏不良事件 (eGFR下降,功能衰竭或透析开始).
主要成果:
- 患有高PAC负担的患者患有重大脏不良事件的发生率高出1.24倍,而不是低PAC负担组.
- 在高PAC负担和AF组之间,重大脏不良事件的风险是可比的.
- 与低PAC负担组相比,AF组的重大脏不良事件风险明显更高.
结论:
- 过度的每日PAC负担是主要脏不良事件的独立风险因素.
- 与高PAC负担相关的脏风险与心房动的风险相当.
- 监测PAC负担对于评估病风险可能很重要.
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