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Updated: Jun 10, 2025

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疏水性CPP/HDO合物:在以寡核酸为首的PROTAC交付方面,一个新的前沿

Miyako Naganuma1,2, Nobumichi Ohoka3, Motoharu Hirano1,2

  • 1Division of Organic Chemistry, National Institute of Health Sciences Kanagawa Japan demizu@nihs.go.jp +81 44 270 6578 +81 44 270 6578.

RSC medicinal chemistry
|October 18, 2024
PubMed
概括

一种新的疏水性细胞透性和异重复性寡核酸结合蛋白质溶解向基米拉 (CPP/HDO-PROTAC) 增强了蛋白质降解. 这种新的方法克服了基于寡核酸的PROTACs的交付挑战,显示了癌症治疗的前景.

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Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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