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Updated: Jun 10, 2025

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使用单细胞全基因组测序对衰老细胞体质突变的分析

Lei Zhang1,2, Marco De Cecco3, Moonsook Lee4

  • 1Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.

Aging biology
|October 18, 2024
PubMed
概括

细胞衰老是衰老的标志,由于细胞分裂增加,单核酸变异 (SNVs) 和小插入/删除 (INDELs) 等体质突变翻了一番. 然而,深度衰老的细胞呈现出显著增加的形形状,这表明染色体不稳定性与衰老有关.

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