类风湿性关节炎和姿势形之间的因果关系:双向孟德尔随机化研究和调解分析
Piqian Zhao1,2,3, Zhe Chen4, Ya Wen5
1Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing, China.
Frontiers in immunology
|October 18, 2024
概括
类风湿性关节炎 (RA) 与和平脚有因果关系. 此外,Hallux valgus还介导了 RA 在平脚上的影响,强调了 RA 患者早期干预的必要性.
科学领域:
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,可能与姿势形有关.
- 调查RA与诸如,平脚和脊柱病等疾病之间的因果关系对于了解疾病机制和制定干预措施至关重要.
研究的目的:
- 确定类风湿性关节炎 (RA) 是否与姿势形有关,特别是欧洲人群中的形,平脚和形.
- 探索黄在RA和平脚之间关系中的潜在调解作用.
主要方法:
- 孟德尔随机化 (MR) 分析使用来自IEU OpenGWAS项目和Finngen数据库的汇总级数据.
- 作为主要方法的反向差异加权 (IVW),补充了MR-Egger,最大概率,加权中位数和cML-MA的稳定性.
- 使用两步式MR进行调解分析,以评估RA在平脚上的间接影响.
主要成果:
- 类风湿性关节炎 (RA) 与 (OR 1.132) 和平脚 (OR 1.197) 有着显著的因果关系.
- 在姿势形中,形与平脚 (OR 1.823) 和形 (OR 1.150) 有因果关系.
- 调解分析显示,华氏体调解了RA在平脚上的41.31%影响.
结论:
- 遗传预测的类风湿性关节炎 (RA) 与和平脚有因果关系.
- 华氏体作为从RA到平脚的途径中的调解者.
- 建议在RA患者中早期查和预防足部形的治疗,需要对非欧洲人群进行进一步的研究.
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