开发和验证一个基于网络的nomogram急性损伤在急性不变形上胃肠道出血患者的急性不变形上胃肠道出血
Chaolian Wei1, Honghua Cao2, Lina Huang3
1Department of Gastric and Abdominal Tumor Surgery, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Frontiers in medicine
|October 18, 2024
概括
这项研究开发了一种名谱,用于预测急性损伤 (AKI) 患有急性非静脉上部胃肠道出血 (NVUGIB) 的患者. 该工具有助于早期干预,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 急性损伤 (AKI) 是患有急性非变节性上部胃肠道出血 (NVUGIB) 的患者的常见和严重并发症.
- 及时预测和干预对于改善患者预后至关重要.
研究的目的:
- 开发和验证急性NVUGIB患者早期AKI发病的预测模型.
- 创建一个用户友好的工具,用于临床应用在风险分层.
主要方法:
- 来自MIMIC-IV数据库的1082名急性NVUGIB患者的回顾性分析.
- 使用后勤回归和LASSO识别独立的AKI预测器.
- 基于已识别的预测因素开发一个名录,并验证其性能 (C指数,校准,DCA).
主要成果:
- 确定了五种AKI的关键预测因素:慢性病 (CKD),人体白蛋白使用,慢性肝病,葡萄糖和血液尿素.
- 诺米图表显示出良好的预测准确性,C指数为0.73 (训练) 和0.72 (验证).
- 决策曲线分析表明临床效用在7%-54%的概率范围内.
结论:
- 开发的诺米图是预测急性NVUGIB患者AKI风险的宝贵工具.
- 它有助于早期风险评估和干预,可能改善临床结果.
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