菲律宾队列中的Theta和SARS-CoV-2变种的长期COVID-19连续病例
Cynthia P Saloma1,2, Marc Edsel C Ayes1, Paolo S Taracatac1
1Philippine Genome Center, University of the Philippines Diliman, Quezon City, Metro Manila, Philippines.
Frontiers in medicine
|October 18, 2024
概括
长期COVID症状在超过68%的菲律宾患者中持续存在,疲劳和脑雾是常见的. 这项研究表明,感染SARS-CoV-2变种可能会影响症状的呈现和持续时间.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 自2019年以来,数百万人感染了严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2).
- 长期COVID的特征是慢性,衰弱的后果,这是一个越来越令人担忧的问题.
- SARS-CoV-2关注的变种 (VoCs) 的出现,感染力增加和免疫逃避.
研究的目的:
- 为了调查感染SARS-CoV-2关注的变种 (VoCs) 是否会影响长期COVID后续.
- 在菲律宾队伍中分析长期COVID症状的流行率和特征.
- 为了确定与长期COVID症状频率相关的风险因素.
主要方法:
- 菲律宾通过RT-PCR和下一代测序确认的SARS-CoV-2病例的回顾性-前性队列研究.
- 参与者按感染VoC/感兴趣的变体 (VoI) 分类.
- 在三个时间点采集一年的纵向数据,采访症状的存在,强度和频率.
主要成果:
- 在三个随访点,长期COVID症状报告在88%,82%和68%的参与者中,这表明随着时间的推移,发病率下降.
- 最常见的症状:头痛,疲劳和运动后的不适;神经精神症状是第二常见的.
- 间歇性脑雾,疲劳和头痛在所有SARS-CoV-2变种队伍中都被一致报告.
结论:
- 菲律宾队伍中很大一部分 (>68%) 经历了异质的,使人衰弱的长期COVID症状.
- 这项研究强调了长期监测长期COVID的必要性.
- 卫生系统需要政策响应策略来管理长期COVID的影响.
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