在患有炎症性肠道疾病的患者中同时出现慢性病,系统性审查和元分析
Xiaoping Han1,2, Zifeng Xu1,2, Yu Chang1,2
1Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
Frontiers in medicine
|October 18, 2024
概括
这项元分析发现,慢性病 (CKD) 在炎症性肠病 (IBD) 患者中的患病率为5%,CKD的风险明显更高. 建议对IBD患者进行定期的CKD监测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 炎症性肠病 (IBD) 是一种多器官自身免疫性疾病,影响胃肠道和潜在的其他器官.
- 脏参与IBD,包括慢性脏病 (CKD) 和末期脏病 (ESRD),不太了解,以前的关联产生不一致的结果.
研究的目的:
- 分析诊断为IBD的患者同时患有CKD和ESRD的患病率.
- 确定IBD患者中CKD和ESRD的风险.
主要方法:
- 在PubMed,Cochrane,Web of Science和Embase进行了系统的文献搜索,搜索到2023年10月之前发表的研究.
- 包括的研究集中在IBD患者同时患有CKD或ESRD,分析发病率和几率比率 (OR).
- 使用纽卡斯尔-太华尺度评估研究质量,并进行敏感性和出版偏差分析.
主要成果:
- 包括9项研究. 在239,042名IBD患者中,CKD的综合流行率为5% (95%CI:1-9%).
- 在40341名IBD患者中,ESRD的综合患病率为0.2% (95% CI: -0.08-0.12%).
- 六项病例控制研究表明,IBD患者的CKD风险显著增加 (OR1.36,95% CI:1.08-1.70,p=0.008).
结论:
- 虽然研究表明IBD中CKD风险增加,但最终结论受到研究数量和异质性的限制.
- 建议对患有炎性肠病的患者进行定期的CKD监测.
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