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Updated: Jun 10, 2025

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参与DNA损伤反应/Fanconi贫血信号的体基因突变是人类固体瘤中特定于组织和细胞类型的基因突变

Sudhir Kumar Rai1,2, Wei Du3, Jun Zhang4

  • 1University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, United States.

Frontiers in medicine
|October 18, 2024
PubMed
概括

在DNA损伤反应 (DDR) 和Fanconi贫血 (FA) 信号通路中的癌症突变因癌症类型而异. 这些独特的突变特征会影响患者的生存和治疗策略.

关键词:
这里是BLM.基因损伤反应 (DDR) 是指对DNA损伤的反应.DNA 跨链交叉链接.芬科尼贫血 (FA) 是一个信号.在RAD18中使用RAD18.基因组的不稳定性身体突变ATR是一种体质突变.

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