维生素D补充剂减少儿童喘恶化:随机对照试验的系统审查和元分析
Katherine Fedora1,2, Retno Asih Setyoningrum1,2, Qorri' Aina1
1Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
Annals of medicine
|October 18, 2024
概括
维生素D补充剂显著减少了儿童喘恶化. 这一发现支持维生素D (VD) 作为儿童喘的有益治疗方法,改善治疗结果并降低发作频率.
科学领域:
- 儿科肺病学 儿科肺病学
- 营养免疫学 营养免疫学
- 临床研究 临床研究
背景情况:
- 低维生素D水平与儿童喘发作增加有关.
- 以前的分析表明,维生素D治疗可以减少成人和儿童的喘恶化.
研究的目的:
- 分析维生素D补充剂在儿童群体中减少喘恶化症的疗效.
主要方法:
- 系统地搜索PubMed,Cochrane和谷歌学者数据库,直到2023年4月.
- 包括在PROSPERO (CRD42023411796) 中注册的随机对照试验 (RCT).
- 使用Cochrane RevMan 5.1进行的元分析,有95%的置信区间 (CI).
主要成果:
- 分析了10项涉及1243名患有喘的儿童的RCT.
- 维生素D补充剂显著降低了喘恶化的总数 (RR 0.62;95% CI:0.44,0.87;p=0.01).
- 小组分析表明,标准的每日维生素D剂量显著改善了喘恶化 (RR 0.41; 95% CI: 0.18, 0.92; p=0.03).
结论:
- 维生素D补充剂有效地减少了儿童喘恶化.
- 这些发现表明,维生素D补充剂可以改善喘儿童的FEV1 (1秒内强迫呼气量).
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