细胞化伴随着 Carotid 动脉样硬化斑块的发展
Anastasia Kanonykina1, Elena Velikanova1, Victoria Markova1
1Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovy Boulevard, 650002, Kemerovo, Russia.
Current medicinal chemistry
|October 18, 2024
概括
在动脉样硬化斑块中存在素化,即通过丁氨酸脱胺酶 (PADI) 来改变蛋白质. 这种过程似乎是局部的,而不是系统的,在动脉样硬化中.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 素化,是一种由丁丁氨酸脱胺酶 (PADI) 2和4进行的翻译后修改,将丁氨酸转化为丁氨酸.
- 这种修饰产生新表位,可能触发与自身免疫性疾病相关的自身抗体.
- 无菌性炎症促进动脉样硬化,由素化启动和增强,表明其在动脉样硬化血管疾病中的作用.
研究的目的:
- 为了调查动脉样硬化斑块内的素化存在和模式.
- 探索新内中素化机制,包括细胞外囊泡的参与.
- 在患有缺血性中风的患者中评估血管素化对全身免疫反应.
主要方法:
- 使用蛋白质组定型,组织学,西部斑点和免疫光学分析动脉样硬化斑块和相邻的动脉细分.
- 对细胞外囊泡标记物 (CD9,CD81) 的检查和与PADI2.2的同定位.
- 在缺血性中风患者和健康对照中测量血清抗林蛋白抗体.
主要成果:
- 蛋白质组分析显示了斑块特异性的蛋白质特征,表明了晚期动脉样硬化和无菌性炎症.
- 二和PADI2在新心脏中丰富,与正常动脉段相比,斑块中二,PADI2和PADI4的水平较高.
- PADI2和基氨酸在新极端细胞和CD81阳性细胞外囊泡中同定位;没有观察到中性粒细胞细胞外陷的迹象.
- 血清抗林蛋白抗体在缺血性中风患者中没有升高,这表明局部免疫反应.
结论:
- 动脉动脉样硬化的发展与局部素化有关.
- 在这种情况下,细胞化是斑块内的局部现象,而不是全身免疫触发器.
关键词:
在PADI2上,我们可以使用PADI2.在PADI4上,您可以使用PADI4.动脉样硬化 动脉样硬化動脈動脈 - 頸動脈動脈素化是指素化.新的亲密关系中性粒细胞中性粒细胞.二甲基氨酸. 二甲基氨酸.更多相关视频
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