Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

An Indoor Accessibility Assessment Framework Based on Multimodal Sensing and Explainable Machine Learning: A Case Study of a Tactile Museum for People with Visual Impairments.

Sensors (Basel, Switzerland)·2026
Same author

Perioperative hypoalbuminemia predicts postoperative survival: a large cohort study with global context.

Frontiers in medicine·2026
Same author

A 3D-bioprinted head and neck cancer model for drug screening.

Biomedical materials (Bristol, England)·2026
Same author

Integrated prioritization of candidate quality markers for Smilacis Chinae Rhizoma under the five-principle framework through chemical profiling, effectiveness evaluation, and bionic sensing.

Journal of ethnopharmacology·2026
Same author

Mechanical loading primes MSC-derived exosomes to promote cartilage repair.

Bioactive materials·2026
Same author

Correction: Mitophagy protects renal tubular epithelial cells from intermittent hypoxia-induced injury via the HIF-1α/BNIP3 pathway.

Sleep and biological rhythms·2026

相关实验视频

Updated: Jun 10, 2025

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

45.0K

衰老会以特定区域的方式影响小鼠大脑.

Ling Cai1,2, Yueman Zhang1,2, Yuxi Zhou1,2

  • 1Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
|October 18, 2024
PubMed
概括

白质中的质衰老加速,影响认知能力下降. 饮食限制和年轻血显示出扭转这些与年龄相关的变化的潜力,提供新的治疗途径.

关键词:
衰老的衰老 衰老的衰老大脑区域大脑区域大脑区域认知能力下降 认知能力下降微质细胞中的微质细胞白质是白色物质的组成部分.

更多相关视频

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment
10:24

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Published on: June 22, 2015

21.5K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.7K

相关实验视频

Last Updated: Jun 10, 2025

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

45.0K
Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment
10:24

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Published on: June 22, 2015

21.5K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.7K

科学领域:

  • 神经科学是一个神经科学.
  • 衰老研究研究 衰老研究
  • 细胞生物学 细胞生物学

背景情况:

  • 全球人口老龄化带来了挑战,包括与年龄相关的认知能力下降.
  • 了解大脑衰老的机制对于开发干预措施至关重要.

研究的目的:

  • 为了研究大脑中特定区域的质衰老.
  • 探索可以逆转质细胞和基因表达的与年龄相关的变化的干预措施.

主要方法:

  • 在白质与皮质区域中对质衰老的比较分析.
  • 在专门的神经元群体中检查基因表达模式.
  • 对饮食限制和年轻小鼠血对质细胞的影响的评估.

主要成果:

  • 与皮质区域相比,白质中的质衰老明显加快.
  • 在专门的神经元群体中观察到基因表达的特定区域变化.
  • 饮食限制在质细胞中重新编程了昼夜钟基因.
  • 年轻小鼠血逆转了质细胞中与年龄相关的基因表达模式.

结论:

  • 大脑衰老是特定区域的,白质衰老的速度更快.
  • 诸如饮食限制和年轻血之类的干预措施可以调节质衰老和基因表达.
  • 这些发现为治疗与年龄相关的认知障碍开辟了新的途径.