对不孕妇女慢性子宫内膜炎复发预测因素的分析
Keisuke Shiobara1, Keiji Kuroda1,2,3, Shunsuke Ishiyama1
1Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan.
American journal of reproductive immunology (New York, N.Y. : 1989)
|October 18, 2024
概括
在不孕妇女中,慢性子宫内膜炎 (CE) 复发的预测是怀孕丧失和宫镜手术. 对于怀孕失败或长期不孕症的患者,建议使用CD138免疫分泌剂重新进行测试.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科医生 妇科
- 传染性疾病 传染性疾病
背景情况:
- 慢性子宫内膜炎 (CE) 是子宫内膜的持续性炎症.
- 脑电阻可以显著影响女性的生育能力和怀孕结果.
- 确定预测CE复发的因素对于有效的生育治疗至关重要.
研究的目的:
- 确定在接受生育治疗的不孕妇女中慢性子宫内膜炎 (CE) 复发的预测因素.
- 确定与CE复发相关的临床和诊断标志物.
主要方法:
- 一项涉及1170名不育妇女的病例控制研究,这些妇女从CE中恢复过来.
- 根据怀孕或怀孕流产的结果,招募105名妇女进行重复子宫内膜活检 (CD138免疫染,细菌培养).
- 具有和没有CE复发的患者的比较.
主要成果:
- 整体的CE复发率为29.5%.
- 流产 (OR,4.13) 显著增加了CE复发风险,而透镜手术 (OR,0.10) 降低了它.
- 在16-18个月 (OR,9.75) 后用CD138免疫分泌剂重新检查与复发的增加有关.
结论:
- 建议在经历妊娠丧失或长期不孕症的患者重新评估CD138免疫染.
- 在与子宫内异常相关的CE病例中,建议在没有抗生素的情况下进行透镜手术.
- 这些发现有助于为患有复发性CE的妇女量身定制生育治疗.
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