在怀孕期间诊断出百日咳和流感后的出生结果:一项基于人口的回顾性研究
Jane E Frawley1, Wen-Qiang He2, Lisa McCallum2
1School of Public Health, University of Technology Sydney, Ultimo, New South Wales, Australia.
BJOG : an international journal of obstetrics and gynaecology
|October 18, 2024
概括
孕妇在怀孕期间患上百日咳和流感感染,尤其是在分娩前,增加了早产和低出生体重的风险. 建议在怀孕期间接种疫苗,以减轻这些不良出生结果.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 虽然怀孕期间的流感与不良分娩结果有关,但关于百日咳的数据有限.
- 了解怀孕期间常见的呼吸道感染对母亲和婴儿健康的影响至关重要.
研究的目的:
- 调查孕期孕妇百日咳和流感感染以及出生不良结果之间的关联.
- 为了比较与百日咳和流感感染相关的风险,特别是在接近分娩的时期.
主要方法:
- 澳大利亚新南威尔士州的一项以人口为基础的研究分析了2001年至2016年间1,453,037例单胎婴儿出生数据.
- 考克斯回归模型用于估计与孕产妇百日咳或流感相关的早产和低出生体重的调整危险比率.
- 在分析中调整了包括母亲年龄,先前分娩和先前存在的疾病在内的共变量.
主要成果:
- 怀孕期间的百日咳和流感感染都与早产风险增加有关.
- 当感染发生在出生后两周内时,这些风险显著增加.
- 与 pertussis 相比,流感病例在第三季度更为集中.
结论:
- 临近分娩的孕产妇百日咳和流感感染与不良分娩结果有关.
- 这些发现强调了孕妇在怀孕期间接种疫苗的重要性,以防止感染并改善分娩结果.
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