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perf 和 polyfluoroalkyl 物质与高尿素血症之间的关联:性别特定的分析

Xin Zheng¹, Jin Li², Chunzi Cui¹

¹Department of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, Hunan, China.

International journal of environmental health research

|October 18, 2024

概括

和多醇基物质 (PFAS) 可能会增加成年人患高尿素血的风险. 这种风险在单个PFAS的男性中显著,在PFAS混合物中的男性和女性中显著.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

和多基基物质 (PFAS) 是普遍存在的环境污染物.
暴露于PFAS和高尿血的关联在不同人群中不一致.

研究的目的:

为了研究单个PFAS和PFAS混合物的血清度与高尿血症之间的关系.
探索PFAS对高尿血症风险的潜在性别特异性影响.

主要方法:

利用了国家健康和营养检查调查 (NHANES) 的两个周期 (2015-2018) 的数据.
在单个PFAS分析中使用加权后勤回归和PFAS混合物的Qgcomp模型.
分析了考虑到性别差异的协会.

主要成果:

单个PFAS仅在男性中显示出与高尿路血的显著相关性.
第四个四分位数的n-PFOA与男性的高尿血症风险增加有关 (OR: 2.79).
PFAS混合物与男性 (OR:1.74) 和女性 (OR:2.04) 每四分位数增加的高尿路血的可能性增加有关.

结论:

暴露于PFAS可能会增加成年人群中高尿路血的风险.
性别似乎影响了个人PFAS和高尿素血症之间的关联.
PFAS混合物显示出一个一致的关联性与增加的高尿素危险跨性别.

关键词:

在PFAS中,有很多方法.在Qgcompcomp中使用Qgcomp.共同暴露共同暴露超血症是什么意思危险的风险危险的风险

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