变量之间的关联和无阿片类药物使用,阿片类药物使用和随后在甲治疗的参与者中脱离的过渡:使用多状态模型的回顾性研究
Boyu Li1, Chijie Wang, Xijia Tang
1From the Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China (BL, CW, XT, ZL, WZ, WC, LL); and Clinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (CZ, LL).
Journal of addiction medicine
|October 18, 2024
概括
甲治疗参与者表现出动态的阿片类药物使用行为. 基于个人阿片类药物使用模式的有针对性的干预措施对于减少阿片类药物使用和改善患者在治疗中的保留至关重要.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 临床研究 临床研究
背景情况:
- 关于影响无阿片类药物使用,阿片类药物使用和脱离甲治疗之间的转变因素的研究有限.
- 了解这些转变对于改善治疗结果至关重要.
研究的目的:
- 探索与无阿片类药物使用,阿片类药物使用和甲治疗中脱离状态之间的过渡相关的变量.
- 为了确定影响治疗期间动态阿片类药物使用行为的因素.
主要方法:
- 一项回顾性研究,使用来自中国广东省11家美沙诊所的数据 (2010年6月至2022年6月).
- 定义过渡状态 (无阿片类药物使用,阿片类药物使用) 和基于尿液测试和甲摄入的吸收状态 (放弃).
- 采用多态模型来分析过渡变量.
主要成果:
- 在3136名参与者中,超过52%的人至少有一段时间使用过阿片类药物.
- 无阿片类药物使用和阿片类药物使用之间的转变与人口统计,社会经济因素,临床状态 (HIV/HCV),甲剂量和出勤率有关.
- 影响中断的因素根据参与者的阿片类药物使用状况有所不同,过渡概率随着时间的推移而演变.
结论:
- 在甲治疗中的阿片类药物使用行为是动态的,随着时间的推移而变化.
- 甲供应商应实施针对个人阿片类药物使用模式量身定制的有针对性的干预措施,以提高治疗保留率和减少阿片类药物使用.
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