Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Controller Configurations01:22

Controller Configurations

87
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
87
Support Reactions in Three Dimensions01:27

Support Reactions in Three Dimensions

916
Support reactions in three dimensions help maintain the stability and equilibrium of various structures and systems. These reactions prevent the system from translating and rotating, ensuring the design can withstand external forces and perform its intended function efficiently and safely. Some of the supports providing support reactions in three dimensions are discussed below:
Ball and Socket Joint is one of the supports allowing free rotation about any axis. This freedom of rotation is...
916
PD Controller: Design01:26

PD Controller: Design

194
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
194
Statically Indeterminate Problem Solving01:16

Statically Indeterminate Problem Solving

365
Statically indeterminate problems are those where statics alone can not determine the internal forces or reactions. Consider a structure comprising two cylindrical rods made of steel and brass. These rods are joined at point B and restrained by rigid supports at points A and C. Now, the reactions at points A and C and the deflection at point B are to be determined. This rod structure is classified as statically indeterminate as the structure has more supports than are necessary for maintaining...
365
Equivalent Couples01:28

Equivalent Couples

280
In mechanical engineering, the concept of equivalent couples plays a crucial role in understanding and analyzing various mechanical systems.
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...
280
Support Reactions01:30

Support Reactions

383
A coplanar force system refers to a set of forces that all lie in the same plane and are subject to different reactions between the point of contact and the supports. Understanding how different types of supports affect coplanar forces is crucial for designing safe and reliable structures that can withstand external loads.
The purpose of the supports is to prevent the translational motion of the system by applying an equal and opposite force and to prevent the system's rotation by applying...
383

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

JCO oncology practice·2026
Same author

Cancer chemo-immunotherapy: time will tell.

Cancer immunology research·2026
Same author

[211At]Astatine-Based Conditioning with a Humanized CD45 Antibody for Autologous Hematopoietic Stem Cell Gene Therapy.

Blood·2026
Same author

Topological Data Analysis of Spatial Protein Expression in Multiplexed Spatial Proteomics Studies.

bioRxiv : the preprint server for biology·2026
Same author

Cellular neighborhoods govern antitumor T-cell infiltration following anti-CTLA-4 in melanoma with primary resistance to anti-PD-1.

Cancer discovery·2026
Same author

A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: vaginal cancer sub cohort results.

Journal of gynecologic oncology·2026
Same journal

Claudin 18.2 Targeting: A Pan-Cancer Perspective.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Pediatric Brain Tumor Consortium phase 1 study of CD40 agonist sotigalimab in pediatric and young adult patients with recurrent CNS tumors and newly-diagnosed DIPG.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

A randomized phase 2 study of combination atezolizumab and varlilumab (CDX-1127) with or without cobimetinib in previously-treated unresectable biliary tract cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Camrelizumab, a patinib and radiotherapy in locally advanced, unresectable hepatocellular carcinoma: a phase 2 study.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
查看所有相关文章

相关实验视频

Updated: Jun 10, 2025

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

11.6K

反向选择设计用于容纳多个控制臂.

Sarah Samorodnitsky1, Megan Othus1, Michael LeBlanc1

  • 1SWOG Statistics and Data Management Center and Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

Clinical cancer research : an official journal of the American Association for Cancer Research
|October 18, 2024
PubMed
概括
此摘要是机器生成的。

临床试验的新型反向选择设计有效地将新疗法与最好的现有疗法进行比较. 这种方法减少了样本大小,并通过提前放弃下级控制臂来控制统计错误.

更多相关视频

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms
10:32

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Published on: August 15, 2016

15.4K
A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Published on: November 6, 2015

9.4K

相关实验视频

Last Updated: Jun 10, 2025

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

11.6K
Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms
10:32

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Published on: August 15, 2016

15.4K
A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Published on: November 6, 2015

9.4K

科学领域:

  • 临床试验方法论 临床试验方法论
  • 生物统计学 生物统计学
  • 实验设计 实验设计

背景情况:

  • 随机对照试验 (RCT) 对于评估新疗法至关重要.
  • 将新疗法与现有疗法进行比较是标准的做法.
  • 当存在多种有效疗法时,选择单一的控制臂可能具有挑战性.

研究的目的:

  • 为RCT引入和评估一种新的"反向选择设计".
  • 为了应对当有多种类似疗法时选择合适的对照臂的挑战.
  • 证明拟议设计的效率和有效性.

主要方法:

  • 反向选择设计涉及一个实验臂和两个控制臂.
  • 一个早期的中间分析比较了两个控制臂.
  • 性能较差的控制臂被删除,随机化继续对剩余的控制臂进行.
  • 最终分析将实验治疗与选择的对照组进行比较.

主要成果:

  • 模拟研究评估了反向选择设计的操作特性.
  • 与传统的三臂设计或连续试验相比,该设计显著减少了所需的样本大小.
  • 该设计有效控制了I型错误率.
  • 该设计可靠地选择高级控制臂进行最终比较.

结论:

  • 反向选择设计为具有多种潜在对照疗法的RCT提供了更有效的方法.
  • 这种创新设计通过尽量减少样本大小要求来优化资源配置.
  • 反向选择设计保持了统计完整性,同时提高了试验效率.