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Updated: Jun 10, 2025

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基于蛋白质的纳米颗粒用于本兹尼达肠道输送.

Victor A Pilicita1, Ana S Sonzogni1,2, Mariana Allasia1

  • 1Polymer Reaction Engineering Group, INTEC (Universidad Nacional del Litoral-CONICET), Güemes 3450, Santa Fe, 3000, Argentina.

Macromolecular bioscience
|October 18, 2024
PubMed
概括

新的纳米粒子改善了尼达的输送,用于查加斯病的治疗. 这种方法针对小肠中的药物释放,有可能减少副作用,并提高这种广泛的寄生虫感染的治疗结果.

关键词:
这种药物是尼达 (benznidazole).查加斯病是查加斯病的一种疾病.欧德拉吉特L100-55®涂层使用通过口服释放的口服释放.简-凯赛因生物颗粒

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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