运动中的分子:解开组织工程中血管化控制的动力学
Francisco A P Rodrigues1, Cláudia S Oliveira1, Simone C Sá1
1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Universidade Católica Portuguesa, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, Porto, 4169-005, Portugal.
Macromolecular bioscience
|October 18, 2024
概括
组织工程的进步,特别是3D生物打印,在血管化工程组织方面面临挑战. 本综述探讨了控制血管形成的策略和分子,以改善组织发育.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
背景情况:
- 组织工程 (TE) 旨在创造个性化的解决方案,克服器官移植的局限性.
- 3D生物打印技术模仿本地组织架构,但在更厚的结构中与血管化作斗争.
研究的目的:
- 审查分子,生物材料和TE策略,以控制工程组织中的血管化.
- 讨论3D生物打印和组织成熟的挑战,以控制血管化.
主要方法:
- 对亲血管性和抗血管性分子,生物材料和细胞的研究.
- 对生物反应器进行动态体外血管化控制的探索.
- 对血管化因素的输送技术的审查.
主要成果:
- 确定了各种分子和策略来促进或抑制血管化.
- 突出了生物反应器在动态血管化控制中的作用.
- 讨论了实现控制的体外/体内血管化的挑战.
结论:
- 控制血管化对于推进TE至关重要,特别是3D生物打印.
- 对于复杂组织的发育,需要对精确的血管化策略进行进一步的研究.
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