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肺癌中的TIL疗法:目前的进展和前景

Weilei Hu^1,2,3, Yifei Bian^2,3, Hongbin Ji^1,2,3,4

¹Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 18, 2024

概括

瘤透淋巴细胞 (TIL) 疗法通过使用患者自己的免疫细胞来治疗肺癌显示出有前途. 这种方法可能有利于那些对当前免疫疗法没有反应的患者.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

肺癌是全球癌症死亡的主要原因之一.
目前的免疫疗法,如免疫检查点阻塞有局限性,许多患者由于T细胞透不足而没有反应.

研究的目的:

审查瘤透淋巴细胞 (TIL) 治疗作为肺癌的潜在治疗方法.
讨论TIL治疗肺癌的适合性,开发和优化策略.

主要方法:

审查TIL治疗的历史和临床发展.
对识别瘤识别TIL和优化TIL组成的方法的概述.

主要成果:

作为一种采用细胞疗法 (ACT) 的形式,TIL疗法涉及从切除的瘤中重新注入扩大自主T细胞.
这种方法对肺癌患者具有显著的治疗潜力.

结论:

TIL疗法是肺癌的一种有前途的治疗方式.
对识别和优化TIL的进一步研究可以提高治疗效率.

关键词:

收养细胞转移 (ACT)肺癌是一种肺癌.非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.瘤透淋巴细胞 (TILs) 是一种细胞.瘤反应性T细胞

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