主要中枢神经系统扩散大B细胞淋巴瘤与MYC和BCL2重组,与深度大脑刺激装置相关
Kirill A Lyapichev1,2, Sri Bharathi Kavuri3, Patrick J Karas4
1Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. kirill.lyapichev@gmail.com.
Virchows Archiv : an international journal of pathology
|October 18, 2024
概括
一种罕见的中枢神经系统 (CNS) 扩散型大B细胞淋巴瘤在为基本震治疗的患者的深度大脑刺激 (DBS) 电极周围发展. 这是首次报告与DBS设备相关的中枢神经系统淋巴瘤病例.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 医疗器械 医疗器械
背景情况:
- 主要中枢神经系统 (CNS) 扩散大B细胞淋巴瘤 (DLBCL) 与MYC和BCL2重组异常罕见.
- 深度大脑刺激 (DBS) 是对耐火运动障碍,精神疾病和慢性疼痛的标准治疗方法.
研究的目的:
- 报告第一个已知的中枢神经系统淋巴瘤在DBS电极周围发展的病例.
- 为了强调与植入的神经刺激装置相关的潜在并发症,尽管很少见.
主要方法:
- 一个70岁的妇女的病例报告,她患有基本震,并接受了与胸膜DBS的治疗.
- 临床表现,神经成像和病理评估,包括遗传分析 (MYC和BCL2重组).
主要成果:
- 患者在DBS植入后一年出现症状,包括反复,视力模糊和混乱.
- 图像检测显示,一个4厘米的异质增强质量集中在DBS电极上.
- 诊断证实为主要的中枢神经系统DLBCL与MYC和BCL2重组.
结论:
- 这个案例代表了与DBS电极相关的中枢神经系统淋巴瘤的第一例记录.
- 这些发现表明,需要对长期植入神经刺激装置的患者潜在的瘤并发症保持警.
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