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母亲产前大麻使用和儿童自闭症谱系障碍

Lyndsay A Avalos^1,2, Mahlet Shenkute¹, Stacey E Alexeeff¹

¹Division of Research, Kaiser Permanente Northern California, Pleasanton.

JAMA network open

|October 18, 2024

概括

孕妇在怀孕早期使用大麻并没有与儿童患自闭症谱系障碍 (ASD) 有关. 需要对整个怀孕期间不同的使用模式进行进一步的研究.

科学领域:

神经发育障碍神经发育障碍
生殖健康生殖健康
公共卫生公共卫生

背景情况:

母亲产前大麻的使用量正在增加.
关于儿童神经发育结果的研究有限.
大麻使用与新生儿不良后果有关.

研究的目的:

评估母亲在怀孕早期使用大麻与儿童自闭症谱系障碍 (ASD) 之间的关联.

主要方法:

基于人口的回顾性出生队列研究.
包括在2011-2019年间出生的儿童.
通过自我报告和毒理学查来评估母亲的大麻使用情况.

主要成果:

包括178,948个怀孕;4.7%的查结果为大麻使用阳性.
没有发现母亲使用大麻和儿童自闭症之间的联系 (HR,1.05;95% CI,0.84-1.32).
没有观察到与使用频率或儿童性别的变化有统计学意义的关联.

结论:

在这个队列中,孕妇在怀孕早期使用大麻与儿童ASD没有关联.
需要进一步的研究来检查整个怀孕期间使用大麻的不同模式.
临床医生应建议不要使用产前大麻,因为已知的新生儿不良影响.

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