早期孕产妇产前大麻使用和儿童发育迟缓
Lyndsay A Avalos1,2, Nina Oberman1, Stacey E Alexeeff1
1Division of Research, Kaiser Permanente Northern California, Pleasanton.
JAMA network open
|October 18, 2024
概括
母亲产前使用大麻并没有显示与儿童发育迟缓的相关性,直到5.5岁. 需要对怀孕期间各种大麻使用模式进行进一步研究.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 母亲产前使用大麻与新生儿不良结果有关.
- 关于产前大麻暴露与儿童发育轨迹之间的联系的数据有限.
- 了解这些关联对于产前护理指南至关重要.
研究的目的:
- 研究孕妇在怀孕早期使用大麻与儿童发育迟缓之间的关系.
- 评估产前大麻使用频率与发育结果之间的潜在联系.
主要方法:
- 对超过10万例怀孕进行了一项大型队列研究.
- 产前大麻使用被通过自我报告和尿液毒理学评估.
- 儿童发育结果,包括言语,运动和全球延迟,使用电子健康记录追踪到5.5岁.
主要成果:
- 在母亲产前使用大麻和言语和语言障碍,全球发育迟缓或运动迟缓之间没有发现显著的关联.
- 大麻使用的频率 (每天,每周,每月) 并没有改变观察到的缺乏关联.
- 该研究分析了来自119,976例怀孕的数据,其中5.6%报告使用大麻.
结论:
- 孕妇在怀孕早期使用大麻并没有增加儿童早期发育迟缓的风险.
- 建议进行进一步的研究,以探索整个妊娠期间的各种大麻消费模式.
- 孕妇应被告知与产前大麻使用相关的已知风险,尽管在本研究中没有观察到发育延迟.
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