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Updated: Jun 10, 2025

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

在儿童中使用超低活性18F-FDG PET/CT成像的可行性

Ha Wu^1,2,3,4,5, Guobing Liu^1,2,3,4, Haojun Yu^1,2,3,4

¹Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

The British journal of radiology

|October 18, 2024

概括

儿童全身PET/CT使用超低剂量的18F-FDG是可行的. 8分钟的采集时间提供了诊断图像质量,减少了儿童的辐射暴露.

科学领域:

医疗成像医学成像
核医学是一种核医学.
放射化学放射化学是指辐射化学.

背景情况:

儿科患者需要专门的成像协议,以尽量减少辐射暴露.
整体体质子辐射断层扫描/计算机断层扫描 (PET/CT) 提供了全面的解剖学和代谢信息.
氧葡萄糖 (18F-FDG) 是用于PET成像的广泛使用的放射追踪剂.

研究的目的:

评估超低活性18F-FDG全身PET/CT在儿童中的可行性.
为了确定儿童全身PET/CT的最佳获取时间.
为了评估儿童患者的图像质量和辐射剂量.

主要方法:

38名儿科患者接受了动态全身PET/CT,其18F-FDG活性超低 (0.37 MBq/kg).
60分钟的原始数据被重建成各种时间间隔 (G1-G15) 的静态图像.
使用主观 (利克尔特尺度) 和客观 (SUV,SNR,TBR,CNR) 的指标来评估图像质量.

主要成果:

有效剂量为0.58 ± 0.19 mSv.
对于主观图像质量而言,优秀的读者间协议 (kappa = 0.878).
诊断图像质量 (得分>3) 和病变检测性是在8分钟的获取时间 (G8) 中实现的.

结论:

八分钟的采集为儿童18F-FDG全身PET/CT提供了诊断质量,具有超低活性.
超低剂量PET成像在儿童中是可行的,可能减少辐射剂量.
这些发现支持降低剂量儿科PET/CT的临床应用.

关键词:

在PET/CT成像中使用PET/CT成像孩子们的孩子们的孩子们的孩子们.图像质量图像质量的质量超低活动的超低活动.

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