在老年人中,加速忘记,粉样蛋白沉积和大脑缩之间的关联
Kirsty Lu1, John Baker1, Jennifer M Nicholas2
1Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK.
加快的长期遗忘 (ALF) 可能表明早期的认知衰退. 这项研究发现,ALF与老年人的临床前阿尔茨海默病生物标志物和主观记忆问题有关.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 加快的长期遗忘 (ALF) 具有正常的短期记忆但快速的长期遗忘.
- 与临床前阿尔茨海默病 (AD) 病理学和记忆选择性的ALF的关联仍然不清楚.
- 了解ALF与AD生物标志物的关系对于早期发现认知衰退至关重要.
研究的目的:
- 调查ALF,临床前AD病理 (粉样和缩) 和主观认知衰退之间的关系.
- 检查AD病理学的背景下,记忆选择性如何影响遗忘模式.
- 评估ALF作为认知正常的老年人认知变化的潜在早期标志物.
主要方法:
- 在基于人口的队列中使用视觉 (复杂图形绘图) 和口头 (面部名称关联记忆测试) 测试来评估ALF (Insight 46, n=429).
- 量化β-粉样蛋白病理学 (PET) 和大脑/海马体缩率 (MRI).
- 分析了ALF,生物标志物和主观认知衰退之间的关联 (MyCog问卷).
主要成果:
- 与粉样蛋白阴性个体相比,粉样蛋白阳性个体更容易忘记复杂的形状轮.
- 粉样蛋白病理和缩之间的相互作用预测了复杂图形绘图上增加的ALF.
- 面部名称关联记忆检查的ALF与海马缩缩率相关;图形绘图的ALF与主观认知衰退相关.
结论:
- 在认知上正常的老年人中,ALF测量与临床前AD病理和主观认知衰退的生物标志物有关.
- 记忆的选择性起到作用",轮"细节在粉样蛋白病理中更容易受到ALF的影响.
- 在临床前阿尔茨海默病中,ALF显示出作为认知变化敏感标记物的潜力.
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