在手术后,病变和病变网络局部化症
Asmaa Mhanna1, Joel Bruss1,2, Joseph C Griffis1
1Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Brain : a journal of neurology
|October 18, 2024
概括
叶手术可能会影响命名能力. 左前部中回形切割与命名衰退有关,为减少这种风险提供了手术规划的信息.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 认知神经学 认知神经学
背景情况:
- 叶手术对于耐药是有效的.
- 叶手术的一个重大风险是术后的认知缺陷,特别是命名能力的下降 (dysnomia).
研究的目的:
- 确定叶外科手术后命名性能下降的神经相关物.
- 为旨在减轻异常症风险的手术规划策略提供信息.
主要方法:
- 经过叶切除手术的85名患者的回顾性分析,使用波士顿命名测试评估术前和术后的命名能力.
- 多变量病变-症状映射以精确确定与命名衰退相关的切除部位.
- 损伤网络映射用于分析涉及切除部位的功能和结构连接性.
主要成果:
- 命名性能在右叶切除术后得到改善,但在左叶切除术后下降.
- 左前侧中回 (布罗德曼区域21) 和基底时语言区域的切割与命名衰退有显著的关联.
- 隐性切除部位显示左侧网络中的功能连接,类似于扩展的语义/默认模式网络,以及通过temporo-frontal白质道的结构连接.
结论:
- 左前中圈和基底时语言区域对于命名至关重要,它们的切除可以导致失名症.
- 这些区域是更广泛的扩展语义网络中的关键节点,突出显示了网络连接在手术结果中的重要性.
- 结果可以帮助手术规划和预后讨论叶患者.
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