维生素D与慢性乙型肝炎的功能治愈的关联:从回顾性队列研究和干预研究的见解
Peipei Wang1, Junjian Chen2, Zhipeng Li1
1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China.
维生素D水平与慢性乙型肝炎 (CHB) 患者的成功功能治愈有关. 补充维生素D可以提高治愈率,当与标准治疗相结合时.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 慢性乙型肝炎 (CHB) 是一个重要的全球健康问题.
- 核胺类类似物 (NAs) 和基化干扰素α (Peg-IFNα) 是CHB的标准治疗方法.
- 维生素D在实现CHB功能治愈中的作用仍在研究中.
研究的目的:
- 研究CHB患者的维生素D水平和功能治愈之间的关联.
- 评估维生素D补充剂对接受标准治疗的CHB患者功能治愈率的影响.
主要方法:
- 在526名CHB患者的血清25-基维生素D (25(OH) D水平的回顾性分析.
- 一项涉及90名患有维生素D缺乏症的CHB患者的干预研究,比较标准NA/Peg-IFNα治疗与NA/Peg-IFNα加上每日维生素D补充 (800 IU/天).
主要成果:
- 追溯分析显示,治疗期间25...OH) D水平增加,治愈后组的水平更高.
- 与对照组 (34.3%) 相比,补充维生素D的组显示出更高的功能治愈率 (48.0%) 的趋势.
- 纵向分析表明,血清25(OH) D水平对治疗结果有显著的积极影响.
结论:
- 血清25(OH) D度和这些度的变化 (Δ25(OH) D) 与CHB中的功能治愈有关.
- 维生素D补充剂可能是一种有益的辅助疗法,用于在CHB患者中实现功能治愈.
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